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Writer's pictureFatima Iqbal

Understanding the Role of Progesterone in Hormone Balance

At Crabtree Health, we understand the critical importance of balancing hormones for women, whether premenopausal or postmenopausal. Hormone imbalances, particularly involving progesterone, can have far-reaching effects on health, mood, metabolism, and overall well-being. Here's everything you need to know about progesterone and how we help women achieve optimal hormone balance.


Estrogen Dominance women

What is Progesterone and Why is it Important?

Progesterone is a key hormone produced in the ovaries before menopause. After menopause, its production shifts primarily to the adrenal glands. This hormone plays an essential role in regulating numerous body functions, and low levels can lead to a variety of health issues, including:

- Anxiety, depression, and mood swings

- Insomnia

- Reduced HDL ("good" cholesterol) levels

- Excessive menstrual bleeding

- Migraines

- Weight gain

- Reduced libido


Natural vs. Synthetic Progesterone

When it comes to hormone replacement therapy (HRT), it’s crucial to distinguish between natural progesterone and synthetic versions known as progestins.


- Natural Progesterone:

- Closely mimics the progesterone produced by the body.

- Balances estrogen, improves sleep, stimulates bone formation, lowers blood pressure, and supports metabolism to reduce obesity risk.

- Leaves the body quickly and is associated with fewer side effects.

- May protect against breast cancer.


- Synthetic Progestins:

- Do not mimic the actions of natural progesterone.

- Associated with significant risks, including an **800% increase in cancer risk** compared to estrogen alone.

- Linked to side effects like shortness of breath, chest pain, high blood pressure, and cardiac issues, as noted by Dr. Stephen Sinatra, a renowned cardiologist.


Balancing Progesterone for Optimal Health

While natural progesterone offers numerous benefits, balance is key. Excessive progesterone can lead to issues such as:

- Increased fat storage

- Reduced glucose tolerance (increasing diabetes risk)

- Elevated cortisol levels (leading to stress-related effects)

- Increased appetite and suppressed immunity

- Worsened back and hip pain due to ligament relaxation

- Decreased growth hormone levels


At Crabtree Health, we emphasize the importance of achieving hormonal harmony. We carefully measure progesterone levels before starting HRT and continue monitoring monthly to ensure the right dose.


How Progesterone is Prescribed

Progesterone can be administered as a pill or cream, and we always use natural, not synthetic, forms:

- For Sleep or Insomnia: Oral progesterone is most effective as it crosses the blood-brain barrier, promoting a calming effect.

- Compounded Progesterone: Natural progesterone derived from yams can be customized at compounding pharmacies to suit individual needs.

- Prometrium: A widely available natural progesterone made from peanut oil.


We avoid over-the-counter progesterone products as they are unregulated and often lack the necessary enzymes for activation. Side effects are minimal and can be managed by adjusting the dose.


The Role of Stress and Gut Health

Stress management and gut health are integral to effective hormone therapy. Optimizing these factors enhances progesterone absorption and minimizes side effects, helping women feel their best.


The Dangers of Estrogen Dominance

Estrogen dominance occurs when progesterone levels are too low relative to estrogen, particularly a type called **16-hydroxyestrone**, which is linked to an increased risk of breast cancer. Balancing progesterone with estrogen is vital to reducing this risk and promoting overall health.


Progesterone and Metabolism

Progesterone and estradiol (E2) work together to:

- Lower body fat.

- Improve insulin sensitivity and control blood sugar levels.


For women with diabetes, we prescribe smaller doses of progesterone to prevent insulin resistance and balance it with estrogen therapy.


Why Balance is Key

High doses of progesterone, as seen with some pharmaceutical-grade hormonal replacements, can lead to:

- Muscle mass loss, worsening conditions like fibromyalgia.

- Increased weight gain, cholesterol, LDL, and triglycerides.

- Insulin resistance, depression, and heart disease.


At Crabtree Health, we focus on precise dosing to ensure progesterone works harmoniously with estrogen, supporting overall health and well-being.


Our Commitment to Women’s Health

Balancing hormones is an art and a science. At Crabtree Health, we prioritize your health by:

- Offering tailored hormone therapies.

- Providing regular monitoring to optimize results.

- Using only natural, safe, and effective progesterone options.


If you’re ready to achieve hormonal balance and regain control of your health, contact us today to learn more about our personalized approach to women’s hormone therapy.

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